Last time, we published a short post about human microbiomes. They are thought to have great influence on human body, particularly on its health status and development. This time, we will cover some information about the Human Microbiome Project, an initiative of the United States National Institutes of Health (NIH).
The human body is home to a gigantic number and diversity of microbes. Inside the body of a healthy adult, microbial cells are thought to outnumber human cells 10 times. What’s more, the joined hereditary contributions of these microorganisms may give crucial characteristics not encoded in our own particular genome yet needed for normal development, physiology, immunity, and nourishment. The mission of the Human Microbiome Project (HMP) is to produce resources to depict these microbial groups and to investigate their parts in health and disease.
Essential parts of the Human Microbiome Project will be culture-independent strategies for microbial community characterization, for example, metagenomics, as well as extensive genome sequencing (which gives a “profound” genetic viewpoint on specific parts of a given microbial group, i.e. of individual bacterial species). The latter will serve as reference genomic successions — 3000 such groupings of individual bacterial isolates are presently planned — for examination purposes amid consequent metagenomic analysis. The microbiology of five body locales will be emphasized: oral, skin, vaginal, gut, and nasal/lung. The project also is financing profound sequencing of bacterial 16S ribosomal RNA groupings enhanced by polymerase chain response from human subjects.
The Goals of the Human Microbiome Project
According to the website of the National Institutes of Health:
The NIH Human Microbiome Project is one of several international efforts designed to take advantage of large scale, high through multi ‘omics analyses to study the microbiome in human health. As a community resource program, the HMP is a partner in an international collaboration to generate rich, comprehensive, and publicly available datasets of the microbiome. This information will be available worldwide for use by investigators and others in efforts to understand and improve human health.
The long-term objective of this initiative is to develop datasets and tools that the community can use to evaluate which biological properties of the microbiome and host will yield important new insights in understanding human health and disease. This initiative is also designed to stimulate the collection of multi ‘omics properties of the microbiome and the host by the research community.
So, what does that mean to you? Maybe there’s no direct impact for a regular guy but you’ll eventually notice that it has a significant effect in the field of medicine. Understanding more about microbiomes can answer many questions in the field of medicine.
Examining organisms inside their communities rather than independently assumes a key part in understanding the human microbiome. A real objective of the Human Microbiome Project is to help analysts focus the likenesses and contrasts among the microbiome of healthy and sick people. They can then portray these groups among groups of individuals, and figure out how they change in diverse health and sickness states.